Pharmacological properties
The drug exhibits a moderate vasodilator (coronarolytic) effect by reflex stimulation of sensory nerve ("cold") receptors of the oral mucosa and has a calming effect on the central nervous system. Stimulation of receptors is accompanied by the induction of release of endorphins, enkephalins, dinorphins and other opioid peptides that play an important role in reducing pain, normalizing vascular permeability, and regulating other important mechanisms of cardiovascular and nervous system functioning. Under the influence of the drug, physiologically active compounds - histamine, kinin, etc., are released.
With sublingual administration, the drug is absorbed from the oral mucosa. The therapeutic effect comes in about 5 minutes.
After absorption, the drug is biotransformed in the liver and excreted in the urine in the form of glucuronides.
