A bacteriostatic antibiotic from the macrolide group reversibly binds to the 50S subunit of the ribosomes in its donor part, which disrupts the formation of peptide bonds between amino acid molecules and blocks the synthesis of microorganism proteins (does not affect the synthesis of nucleic acids). When used in high doses, it may exhibit bactericidal action. The spectrum of action includes Gram-positive (Staphylococcus spp., Producing and not producing penicillinase, including Staphylococcus aureus; Streptococcus spp. (Including Streptococcus pneumoniae, Streptococcus pyogenes, alpha-hemolytic streptococcus of the Viridans group); Bacillus anthracis, Corynebacterium diphtheriae, Corynebacterium minutissimum) and Gram-negative microorganisms (Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp., Including Legionella pneumophilla) and other microorganisms: Mycoplasma pneumoniae, Chlamydia spp. (Including Chlamydia trachomatis), Treponema spp., Rickettsia spp., Entamoeba histolytica, Listeria monocytoqehes.
Indications for use
Erythromycin resistant gram-negative rods: Esherichia coli, Pseudomonas aeruginosa, Shigella spp., Salmonella spp., and others. Sensitive groups include microorganisms, which growth is delayed at an antibiotic concentration of less than 0.5 mg / l, medium sensitivity - 1-6 mg / l, moderately resistant and stable - 6-8 mg / l.
Bacterial infections caused by erythromycin-sensitive microflora: diphtheria (including bacteriocarrier), pertussis (including prophylaxis), trachoma, brucellosis, legionnaires, erythrasma, listeriosis, scarlet fever, amoebic dysentery, gonorrhea; Conjunctivitis of newborns, pneumonia in children, urogenital infections in pregnant women, caused by Chlamydia trachomatis; Primary syphilis (in patients with penicillin allergy), uncomplicated chlamydia in adults (with localization in the lower sections of the urogenital tract and rectum) with intolerance or inefficiency of tetracyclines, etc .; Infection of the ENT organs (tonsillitis, edema, sinusitis), bile duct infection (cholecystitis); infection of the upper and lower respiratory tract (tracheitis, bronchitis, pneumonia), skin and soft tissue infections (pustular skin diseases, including acne vulgaris, infected wounds, bedsores, burns II-III, trophic ulcers), infections of the eye mucosa.
Prevention of exacerbations of streptococcal infection (tonsillitis, pharyngitis) in patients with rheumatism. Prevention of infectious complications in medical and diagnostic procedures (including preoperative intestinal preparation, dental interventions, endoscopy in patients with heart defects).